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| Birthday April 22, 1873 Ellen Glasgow, Pulitzer Prize-winning American novelist, is born |
| Birthday April 22, 1904 J. Robert Oppenheimer |
| Birthday April 22, 1937 Jack Nicholson born |
| History April 22, 1778 John Paul Jones leads American raid on Whitehaven, England |
| History April 22, 1863 Union raid cuts Mississippi telegraph wires |
| History April 22, 1886 Seduction is made illegal |
| History April 22, 1889 The Oklahoma land rush begins |
| History April 22, 1915 Second Battle of Ypres begins |
| History April 22, 1915 Germans introduce poison gas |
| History April 22, 1933 Rolls-Royce co-founder dies |
| History April 22, 1934 An FBI agent is killed in a gangster raid |
| History April 22, 1944 Americans launch Operation Persecution in the Pacific |
| History April 22, 1945 Hitler admits defeat |
| History April 22, 1954 McCarthy Army hearings begin |
| History April 22, 1968 South Vietnamese have increased combat capabilities |
| History April 22, 1972 Antiwar demonstrations held |
| History April 22, 1978 The Blues Brothers make their world premiere on Saturday Night Live |
| History April 22, 1992 Sewers explode in Guadalajara |
| History April 22, 1994 Former President Richard Nixon dies |
| History April 22, 1997 Fujimori orders assault on Japanese ambassador's home |
| History April 22, 2004 Pat Tillman killed by friendly fire in Afghanistan |